Topic
GLP-1s
Semaglutide, tirzepatide, retatrutide, and the incretin pipeline — the pharmacology, the market, and the claims made about their effects beyond weight.
GLP-1 receptor agonists are the most consequential — and most discussed — drugs in modern metabolic medicine. This hub separates the well-evidenced core (weight and glucose outcomes from large trials) from the fast-growing layer of secondary claims that have not yet been established.
Publications on this topic
Incretins: GLP-1 and GIP
Incretins are hormones the gut releases after a meal to amplify the pancreas's insulin response. This explainer covers the incretin effect and how it is measured, the two incretin hormones GLP-1 and GIP, why their insulin action is glucose-dependent, how they differ, why an enzyme destroys them within minutes, and why the effect is blunted in type 2 diabetes.
Lean Mass During GLP-1 Weight Loss
Rapid GLP-1 and GLP-1/GIP weight loss reduces lean mass as well as fat — but so does any large weight loss, and 'lean mass' on a body scan is not contractile muscle. This explainer reports the exact DEXA-substudy percentages from SURMOUNT-1 and STEP 1, separates the expected adaptation to a smaller body from a genuine clinical concern, and weighs what resistance training and adequate protein can preserve against what they cannot.
Semaglutide
Semaglutide is a re-engineered gut-hormone drug taken once a week — the same molecule behind Ozempic, Wegovy, and the oral tablet Rybelsus. This explainer traces what it is, how it works, and what the pivotal trials demonstrate on weight, blood sugar, the heart, the kidney, and the liver, with the side effects and open questions kept beside the benefits.
What Is Tirzepatide?
Tirzepatide is a single engineered molecule that activates two gut-hormone receptors at once. This explainer traces the dual-agonist idea, the verified weight, glucose, and sleep-apnea results, the head-to-head win over semaglutide, and the cardiovascular claim it has not yet earned.
What Is GLP-1 and How Does It Work?
GLP-1 is a hormone your gut releases after a meal. This explainer traces what it is, how its signaling lowers blood sugar and appetite, why the natural hormone had to be re-engineered into a drug, and what the pivotal trials — and their limits — actually demonstrate.
After the Weight Comes Off
A systematic, evidence-graded study of the second- and third-order effects of GLP-1 medicines across nineteen industries and the culture itself — grading, honestly, which consequences are real, which are exaggerated, and which are not yet proven.
From the Lab to the Feed
A South Beach Longevity intelligence report separating the peptide phenomenon into four distinct movements — a pharmaceutical revolution, a scientific field, a gray online marketplace, and a wellness subculture — and testing whether the boom is as broad as it looks.
Peptide Buying Opportunities
A shareable market analysis of the research-use-only peptide retail market — pricing dispersion, seller consistency, and where value concentrates — built from a live retail-price corpus. Contains no internal cost or margin data.