The Science of Therapeutic Peptides · Volume VI

Immune, Inflammatory & Antimicrobial

Immune modulation, inflammation, and antimicrobial peptides.

8 chapters

1. VI.1ARA-290Eleven residues from the face of a blood hormone, and the receptor nobody was looking for→
2. VI.2KPVThe three-residue tail of a pigment hormone, and what happened when it was cut off→
3. VI.3LarazotideThe cholera toxin fragment that tried to close the gut→
4. VI.4LL-37The only cathelicidin a human being has, and the trouble with an antibiotic that also talks to the immune system→
5. VI.5ThymalinA calf-thymus polypeptide complex from a Leningrad military academy, three short peptides later read out of it, and four decades of evidence that almost never left one programme→
6. VI.6Thymosin Alpha-1Twenty-eight residues, sixty years, a thousand papers, and the awkward relationship between how much evidence there is and how good it is→
7. VI.7ThymulinThe zinc-locked nonapeptide of the thymus — discovered as a serum factor in Paris, renamed when a metal proved indispensable, and still searching for a modern human trial→
8. VI.8VIPThe gut hormone that turned out to run vessels, lungs, clocks, and immune calm→